Zeeuws-Vlaanderen is easy to acces from both Belgium and Holland. Both Rotterdam and Brussels are within an hour drive.
Via the A58 you will enter the province Zeeland, take the exit on the motorway at Goes and follow the N62. This is the highway from Goes to Gent. Via the Westerscheldetunnel you will enter the city centre of Terneuzen. Drive on fot another 20/30 minutes and you will be in Gent.
Take the E34 at Antwerp and follow the route towards the Belgian coastal area. Take the exit towards Holland (N62) or the highway to Gent (R4), both are within 15 minutes from the E34.